Use of desmopressin (DDAVP) during early pregnancy in factor VIII-deficient women.
نویسنده
چکیده
3. Wen FQ, Jabbar AA, Chen YX, Kazarian T, Patel DA, Valentino LA. C-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. Blood. 2002;100:912-916. 4. Nishiya K. Stimulation of human synovial cell DNA synthesis by iron. J Rheumatol. 1994;21:1802-1807. 5. Cruz E, Vieira J, Gonçalves R, et al. Involvement of the MHC region in the genetic regulation of circulating CD8 T cell numbers in humans. Tissue Antigens. 2004;64:25-34. 6. de Sousa M, Dynesius-Trentham R, Mota-Garcia F, da Silva MT, Trentham DE. Activation of rat synovium by iron. Arthritis Rheumat. 1988;31:653-661. 7. Drakesmith H, Sweetland E, Schimanski L, et al. The hemochromatosis protein HFE inhibits iron export from macrophages. Proc Natl Acad Sci U S A. 2002;99: 15602-15607.
منابع مشابه
DDAVP Might Reduce the Risk of Preeclampsia in Pregnant Women with VWF Deficiency
Preeclampsia is the most common medical disorder of pregnancy [1]. Preeclampsia can present very early in pregnancy with hypertension and proteinuria. Preeclampsia includes a spectrum of clinical symptoms varying from subtle weight gain and swelling of the face and extremities to severe headache, abdominal pain, nausea, vomiting, and visual impairment. Endothelial cell changes along with widesp...
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متن کاملDesmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years.
I the enhancement of blood clotting associated with stress was caused by the liberation of adrenaline in plasma. In 1957, N 1977 DESMOPRESSIN (1-deamino-8-D-arginine vasopressin, abbreviated DDAVP), a derivative of the antidiuretic hormone, was used for the first time to treat patients a possible mechanism for faster clotting after adrenaline was provided by Marciniak, who found a transient inc...
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Background Von Willebrand ́s disease (VWD) is the most common congenital disorder of hemostasis, characterized by deficient or defective von Willebrand factor. Patients are treated by intravenous replacement of factor VIII/VW (FVIII/ VW) when needed, for prophylaxis before surgical procedures. Anaphylactic reactions to FVIII/VW are rare and desmopressin (DDAVP) can be used as an alternative.
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Desmopressin increases endogenous factor VIII levels in hemophilia A. Large inter-individual variation in the response to desmopressin is observed. Patients with a lower baseline factor VIII activity tend to show a reduced response, therefore, desmopressin is less frequently used in moderate hemophilia A patients (baseline factor VIII activity 1-5 international units/deciliter), even though fac...
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ورودعنوان ژورنال:
- Blood
دوره 105 8 شماره
صفحات -
تاریخ انتشار 2005